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Assessment of the Effects of Levosimendan and Nigella Sativa on Myocardial Ischemia Reperfusion Injury in Rats
Ozer, Abdullah; Kilic, Yigit; Sezen, Saban Cem; Kucuk, Aysegul; Mardin, Baris; Alkan, Metin; Oktar, Levent (Gazi Univ, Fac Med, 2018)Objective: Ischemia-reperfusion injury is a chain of events put in place by tissue ischemia. Reperfusion following the damage of cell causes an active inflammatory response. In our research we tried to evaluate the protective ... -
Assessment of the effects of levosimendan and thymoquinone on lung injury after myocardial ischemia reperfusion in rats
Sezen, Saban Cem; Kucuk, Aysegul; Ozer, Abdullah; Kilic, Yigit; Mardin, Baris; Alkan, Metin; Tosun, Murat (Dove Medical Press Ltd, 2018)Aim: The aim of this study was to investigate the effects of levosimendan and thymoquinone (TQ) on lung injury after myocardial ischemia/reperfusion (I/R). Materials and methods: Twenty-four Wistar albino rats were included ... -
Dexmedetomidine protects against lipid peroxidation and erythrocyte deformability alterations in experimental hepatic ischemia reperfusion injury
Arslan, Mustafa; Comu, Faruk Metin; Kucuk, Aysegul; Ozturk, Levent; Yaylak, Faik (Taylor & Francis Ltd, 2012)Background: Hepatic ischemia-reperfusion injury is a common clinical problem in hepatic surgery and transplantation. Several cellular and tissue structural and functional alterations are observed in such injury. The aim ... -
The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats
Tuncay, Aydin; Sivgin, Volkan; Ozdemirkan, Aycan; Sezen, Saban Cenn; Boyunaga, Hakan; Kucuk, Aysegul; Gunes, Sin (DOVE MEDICAL PRESS LTD, 2020)Introduction: We aimed to investigate the effects of cerium oxide, applied before the sevoflurane anesthesia, on lung tissue in rats with lower extremity ischemia-reperfusion (IR). Materials and Methods: A total of 30 rats ... -
Effect of different doses of pregabalin on erythrocyte deformability in rats with lower limb ischemia reperfusion injury
Ozer, Abdullah; Comu, Faruk Metin; Demirtas, Huseyin; Kilic, Yigit; Mardin, Baris; Ozturk, Levent; Kucuk, Aysegul (Anaesthesia Pain & Intensive Care, 2017)Background & Objective: Acute ischemia reperfusion (IR) injury observed in the lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Preoperative pregabalin ... -
Effect of Fullerenol C60 on Erythrocyte Deformability During Ischaemia-Reperfusion Injury of Lower Extremity in Diabetic Rats
Kip, Gulay; Kartal, Hakan; Comu, Faruk Metin; Polat, Yucel; Arslan, Mustafa; Kucuk, Aysegul (Gazi Univ, Fac Med, 2019)Background: Fullerenol, a water-soluble C60-fullerene derivative synthesized by Chiang et al, has been demonstrated to be able to scavenge free radicals in vitro and in vivo. Although its protective effects have been already ... -
Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia-reperfusion injury in rats
Erer, Dilek; Ozer, Abdullah; Demirtas, Huseyin; Gonul, Ipek Isik; Kara, Halil; Arpaci, Hande; Kucuk, Aysegul (Dove Medical Press Ltd, 2016)Objectives: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in an experimental ... -
Effects of hydroxyethyl starch 130/0.4 on the kidney tissue of rats with ureteral obstruction
Gunes, Isin; Sungu, Nuran; Kilicarslan, Aydan; Sivgin, Volkan; Alkan, Metin; Kucuk, Aysegul; Arslan, Mustafa (Dove Medical Press Ltd, 2018)Objective: This study was conducted since the effects of colloid solutions on the renal system remain controversial and need to be adequately studied in animals. We aimed to evaluate the effects of hydroxyethyl starch ... -
Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability and hepatic and renal blood flow in rats
Arpaci, Hande; Comu, Faruk Metin; Kucuk, Aysegul; Kosem, Bahadir; Kartal, Seyfi; Sivgin, Volkan; Arslan, Mustafa (Dove Medical Press Ltd, 2016)Background: Change in blood supply is held responsible for anesthesia-related abnormal tissue and organ perfusion. Decreased erythrocyte deformability and increased aggregation may be detected after surgery performed under ... -
P53 related apoptosis in kidneys in CO2 pneumoperitoneum rat model: an immunohistochemical study
Tosun, Murat; Yucel, Mehmet; Kucuk, Aysegul; Sezen, Saban (Springer, 2014)Laparoscopic surgery techniques have been increasingly preferred to classic laparotomy by surgeons since 1987. However, this method may have some side effects on different intraabdominal organs including kidneys. The aim ...